POLO-LIKE KINASE 4 (PLK4) INHIBITORS, PHARMACEUTICAL COMPOSITIONS, METHODS OF PREPARATION AND USES THEREOF
Disclosed are compounds and pharmaceutically acceptable salts of formula (I), which feature either a N-(1H-pyrazol-3-yl)pyridin-2-amine or a N-(1H-pyrazol-3-yl)pyrimidin-4-amine core structure. These compounds may be used in the treatment of diseases such as cancer or diseases associated with TRIM37...
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Format | Patent |
Language | English |
Published |
03.10.2024
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Abstract | Disclosed are compounds and pharmaceutically acceptable salts of formula (I), which feature either a N-(1H-pyrazol-3-yl)pyridin-2-amine or a N-(1H-pyrazol-3-yl)pyrimidin-4-amine core structure. These compounds may be used in the treatment of diseases such as cancer or diseases associated with TRIM37. The compounds disclosed herein may be inhibitors of polo-like kinase 4 (PLK4). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof, methods of their preparation, and use. |
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AbstractList | Disclosed are compounds and pharmaceutically acceptable salts of formula (I), which feature either a N-(1H-pyrazol-3-yl)pyridin-2-amine or a N-(1H-pyrazol-3-yl)pyrimidin-4-amine core structure. These compounds may be used in the treatment of diseases such as cancer or diseases associated with TRIM37. The compounds disclosed herein may be inhibitors of polo-like kinase 4 (PLK4). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof, methods of their preparation, and use. |
Author | LIU, Bingcan SOW, Boubacar BUBENIK, Monica GALLANT, Michel MOCHIRIAN, Philippe SURPRENANT, Simon DUPLESSIS, Martin VALLÉE, Frédéric PERRYMAN, Alexander |
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Snippet | Disclosed are compounds and pharmaceutically acceptable salts of formula (I), which feature either a N-(1H-pyrazol-3-yl)pyridin-2-amine or a... |
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Title | POLO-LIKE KINASE 4 (PLK4) INHIBITORS, PHARMACEUTICAL COMPOSITIONS, METHODS OF PREPARATION AND USES THEREOF |
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