CELL PENETRATING PEPTIDE MEDIATED RNA TRANSDUCTION WITHIN INSECT CELLS

A method of introducing a molecule of interest into an insect or an insect cell includes interacting a cell-penetrating peptide with a molecule of interest to form a complex. The structure is then placed in contact with an insect or an insect cell and allowing uptake of the complex into the insect o...

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Bibliographic Details
Main Authors SAMUEL, Jayakumar Pon, THILGES, Katherine A, DAVIS-VOGEL, Courtney Anne, MENDEZ, Edwin J
Format Patent
LanguageEnglish
Published 06.06.2024
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BEER
BIOCHEMISTRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TRAPPING
VINEGAR
WINE
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Summary:A method of introducing a molecule of interest into an insect or an insect cell includes interacting a cell-penetrating peptide with a molecule of interest to form a complex. The structure is then placed in contact with an insect or an insect cell and allowing uptake of the complex into the insect or insect cell. Alternatively, an RNA polynucleotide (mRNA, or an RNAi-mediating molecule) can be introduced in an insect or an insect cell by interacting a peptide with the polynucleotide of interest to form a complex, allowing uptake of the RNA complex into the insect or insect cell, and expressing the polynucleotide in the insect or an insect cell.
Bibliography:Application Number: AU20210401884