Ferritin variants with increased stability, complexation ability and transferrin receptor affinity

The present invention relates to a polypeptide comprising a transferrin receptor binding domain (TRBD) of a ferritin variant. The TRBD comprises one or more glutamine residues mutated into glutamic acid residues and/or one or more asparagine residues mutated into aspartic acid residues. 5 The invent...

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Main Authors BONAMORE, Alessandra, MARSZALEK, Ilona, SKORZYNSKI, Marcin, KROL, Magdalena, BOFFI, Alberto, RYGIEL, Tomasz, ARCOVITO, Alessandro
Format Patent
LanguageEnglish
Published 22.09.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract The present invention relates to a polypeptide comprising a transferrin receptor binding domain (TRBD) of a ferritin variant. The TRBD comprises one or more glutamine residues mutated into glutamic acid residues and/or one or more asparagine residues mutated into aspartic acid residues. 5 The invention further relates to a complex of this polypeptide and a label or drug, and an isolated cellular delivery system comprising the polypeptide or the complex of the invention as well as uses of such system for prophylaxis, therapy, diagnosis or theragnosis, in particular for therapy of cancer or inflammatory diseases.
AbstractList The present invention relates to a polypeptide comprising a transferrin receptor binding domain (TRBD) of a ferritin variant. The TRBD comprises one or more glutamine residues mutated into glutamic acid residues and/or one or more asparagine residues mutated into aspartic acid residues. 5 The invention further relates to a complex of this polypeptide and a label or drug, and an isolated cellular delivery system comprising the polypeptide or the complex of the invention as well as uses of such system for prophylaxis, therapy, diagnosis or theragnosis, in particular for therapy of cancer or inflammatory diseases.
Author ARCOVITO, Alessandro
BONAMORE, Alessandra
BOFFI, Alberto
SKORZYNSKI, Marcin
KROL, Magdalena
MARSZALEK, Ilona
RYGIEL, Tomasz
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– fullname: SKORZYNSKI, Marcin
– fullname: KROL, Magdalena
– fullname: BOFFI, Alberto
– fullname: RYGIEL, Tomasz
– fullname: ARCOVITO, Alessandro
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Snippet The present invention relates to a polypeptide comprising a transferrin receptor binding domain (TRBD) of a ferritin variant. The TRBD comprises one or more...
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SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title Ferritin variants with increased stability, complexation ability and transferrin receptor affinity
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