Inhibitors of glucocorticoid receptor

The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of...

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Main Authors Fantin, Valeria R, Sun, Daqing, Yan, Xuelei, McGee, Lawrence R, Balbas, Minna Delarae, Du, Xiaohui, Medina, Julio C, Zhou, Haiying, Rew, Yosup, Eksterowicz, John, Zhu, Liusheng
Format Patent
LanguageEnglish
Published 29.04.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
STEROIDS
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Abstract The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
AbstractList The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
Author Sun, Daqing
Yan, Xuelei
Fantin, Valeria R
Zhou, Haiying
Medina, Julio C
Balbas, Minna Delarae
Eksterowicz, John
Rew, Yosup
McGee, Lawrence R
Du, Xiaohui
Zhu, Liusheng
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– fullname: Balbas, Minna Delarae
– fullname: Du, Xiaohui
– fullname: Medina, Julio C
– fullname: Zhou, Haiying
– fullname: Rew, Yosup
– fullname: Eksterowicz, John
– fullname: Zhu, Liusheng
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Snippet The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal...
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SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
STEROIDS
Title Inhibitors of glucocorticoid receptor
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