Camptothecin derivatives with a disulfide moiety and a piperazine moiety

• Main Authors: PATEL, Jiten Ranchhodbhai, SENGUPTA, Prabal, GORE, Omkar Prakash, PATEL, Gopalkumar Chimanlal, CHITTURI, Trinadha Rao
• Format: Patent
• Language: English
• Published: 03.03.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention provides a compound of Formula I or a pharmaceutically acceptable salt thereof (wherein X, Y, Z and n are defined herein). These compounds are useful in the treatment of diseases mediated by topoisomerase I enzyme such as cancers. The present invention also provides processes for the...