Amphotericin B derivatives with improved therapeutic index

• Main Authors: Davis, Stephen, Uno, Brice E, Knapp, David M, Struble, Justin, Burke, Martin D, Dailey, Ian, Gray, Kaitlyn C, Wang, Pulin, Palyam, Nagarjuna
• Format: Patent
• Language: English
• Published: 16.01.2020
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

Attorney Docket No. UIX-014.25 Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives ofAmB. Certain of the derivatives are C3, C5, C8, C9, C1I, C13, or C15 5 deoxy derivatives...