Bispecific antibodies with cleavable C-terminal charge-paired tags

The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain comprising consecutive negatively charged amino acid residues; and (b) a second polypeptide comprising a CH3 domain and a positively charged domai...

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Main Authors GRAHAM, Kevin, ROMANINI, Dante, AGRAWAL, Neeraj J, WAGNER, Victoria, THIEL, Oliver, JACOBITZ, Alex W, LOW, Ray Lieh Yoon, MOHR, Christopher, KAWOOYA, John K, SMITH, Stephen
Format Patent
LanguageEnglish
Published 07.01.2021
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Abstract The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain comprising consecutive negatively charged amino acid residues; and (b) a second polypeptide comprising a CH3 domain and a positively charged domain comprising consecutive positively charged amino acid residues. Also provided are methods for conjugating synthetic molecules to a multi-specific antigen binding molecule.
AbstractList The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain comprising consecutive negatively charged amino acid residues; and (b) a second polypeptide comprising a CH3 domain and a positively charged domain comprising consecutive positively charged amino acid residues. Also provided are methods for conjugating synthetic molecules to a multi-specific antigen binding molecule.
Author GRAHAM, Kevin
WAGNER, Victoria
SMITH, Stephen
THIEL, Oliver
ROMANINI, Dante
LOW, Ray Lieh Yoon
JACOBITZ, Alex W
AGRAWAL, Neeraj J
MOHR, Christopher
KAWOOYA, John K
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– fullname: AGRAWAL, Neeraj J
– fullname: WAGNER, Victoria
– fullname: THIEL, Oliver
– fullname: JACOBITZ, Alex W
– fullname: LOW, Ray Lieh Yoon
– fullname: MOHR, Christopher
– fullname: KAWOOYA, John K
– fullname: SMITH, Stephen
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Snippet The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain...
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SubjectTerms CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Title Bispecific antibodies with cleavable C-terminal charge-paired tags
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