Interleukin-2 muteins for the expansion of T-regulatory cells

• Main Authors: Butz, Eric Alan, De Imus, Cyr Clovis Chua, Gavin, Marc Alain, Manchulenko, Kathy, Li, Li, Foltz, Ian Nevin, Alcorn, Dina N, Xia, Dong, Lim, Ai Ching, Ketchem, Randal Robert, Kannan, Gunasekaran, Berry, Kelly Ann, Agrawal, Neeraj Jagdish, Sekirov, Laura, Thomson, Christy Ann
• Format: Patent
• Language: English
• Published: 05.12.2019
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant hu...