Stable protein solution formulation containing high concentration of an anti-VEGF antibody

C:\Interwo n\NRPortbl\DCC\DAR\18137008_l.docx-4/12/2018 The present invention provides anti-VEGF antibodies formulated as high concentration, aqueous pharmaceutical compositions, suitable for an injection, preferably an intravitreal injection. The aqueous pharmaceutical compositions are useful for d...

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Main Authors Boring, Charles, Wan, Li, Kulshreshtha, Alok, Alani, Laman, Zeng, Yuhong, Zhang, Huixiang
Format Patent
LanguageEnglish
Published 09.07.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract C:\Interwo n\NRPortbl\DCC\DAR\18137008_l.docx-4/12/2018 The present invention provides anti-VEGF antibodies formulated as high concentration, aqueous pharmaceutical compositions, suitable for an injection, preferably an intravitreal injection. The aqueous pharmaceutical compositions are useful for delivery of a high concentration of the antibody active ingredient to a patient without high levels of antibody aggregation and without a high level of sub-visible particulate matter. An aqueous composition of the invention comprises an antibody having a concentration of at least 50 mg/ml. An aqueous pharmaceutical composition of the invention includes a sugar, a buffering agent, and a surfactant.
AbstractList C:\Interwo n\NRPortbl\DCC\DAR\18137008_l.docx-4/12/2018 The present invention provides anti-VEGF antibodies formulated as high concentration, aqueous pharmaceutical compositions, suitable for an injection, preferably an intravitreal injection. The aqueous pharmaceutical compositions are useful for delivery of a high concentration of the antibody active ingredient to a patient without high levels of antibody aggregation and without a high level of sub-visible particulate matter. An aqueous composition of the invention comprises an antibody having a concentration of at least 50 mg/ml. An aqueous pharmaceutical composition of the invention includes a sugar, a buffering agent, and a surfactant.
Author Zhang, Huixiang
Boring, Charles
Wan, Li
Zeng, Yuhong
Alani, Laman
Kulshreshtha, Alok
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– fullname: Zhang, Huixiang
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SubjectTerms HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Stable protein solution formulation containing high concentration of an anti-VEGF antibody
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