Pyrazine derivatives useful as inhibitors of ATR kinase

• Main Authors: DURRANT, Steven, REAPER, Philip Michael, MACCORMICK, Somhairle, PINDER, Joanne, KAY, David, VIRANI, Anisa Nizarali, YOUNG, Stephen, KNEGTEL, Ronald, O'DONNELL, Michael, MORTIMORE, Michael, CHARRIER, Jean-Damien, RUTHERFORD, Alistair
• Format: Patent
• Language: English
• Published: 18.06.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Abstract The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; me thods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermedia tes fo r the prepara tion of the com pound s of this inve ntion; an d method s of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the com parative evaluation of n ew kin ase inhibitors. The compo un ds of this invention have formula (I):whereir the variables are as defined herein