IGM antibody, composition and kit comprising it for treatment or diagnosis of a disease

• Main Authors: TAM, Chi Hang Frankie, LAW, Chun-Yiu, LEUNG, Tze Ming, LIM, Pak Leong
• Format: Patent
• Language: English
• Published: 10.08.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides an IgM antibody for use in a method for treatment or 5 diagnosis of a disease in a subject. The subject especially but not exclusively is a human and the disease includes cancer, an infectious disease, an autoimmune disease or an allergic disease. In another aspect, the present invention refers to a pharmaceutical composition for use in a method for treatment of a disease and a kit for diagnosis of a disease in a subject such as in a human comprising the IgM antibody. 10 The inventor unexpectedly found that the IgM antibodies are highly advantageous over IgG antibodies of at least similar specificity which cannot access the target antigen and, thus, fail to sufficiently treat or diagnose the disease. 9270519_1 (GHMatters) P106323.AU Antibody combining site Antigen Fc Light chain 4- Heavy chain Fig. 1A Fig. 1B 1gM ~ilsomerize IgG naked antigen blocked antigen blocked antigen blocked antigen Fig. 1C