Bcl xl inhibitory compounds having low cell permeability and antibody drug conjugates including the same

The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.

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Main Authors Sullivan, Gerard M, Welch, Dennie S, Judd, Andrew S, Bennett, Nathan B, Cullen, Steve C, Kunzer, Aaron R, Doherty, George, Wang, Xilu, Tao, Zhi-Fu, Marin, Violeta L, Song, Xiaohong, Wendt, Michael D, Frey, Robin R, Boghaert, Erwin R, Haight, Anthony R, Ackler, Scott L, Shen, Xiaoqiang, Souers, Andrew J
Format Patent
LanguageEnglish
Published 29.06.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.
AbstractList The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.
Author Frey, Robin R
Doherty, George
Shen, Xiaoqiang
Kunzer, Aaron R
Marin, Violeta L
Judd, Andrew S
Ackler, Scott L
Haight, Anthony R
Souers, Andrew J
Song, Xiaohong
Bennett, Nathan B
Tao, Zhi-Fu
Wendt, Michael D
Cullen, Steve C
Wang, Xilu
Sullivan, Gerard M
Welch, Dennie S
Boghaert, Erwin R
Author_xml – fullname: Sullivan, Gerard M
– fullname: Welch, Dennie S
– fullname: Judd, Andrew S
– fullname: Bennett, Nathan B
– fullname: Cullen, Steve C
– fullname: Kunzer, Aaron R
– fullname: Doherty, George
– fullname: Wang, Xilu
– fullname: Tao, Zhi-Fu
– fullname: Marin, Violeta L
– fullname: Song, Xiaohong
– fullname: Wendt, Michael D
– fullname: Frey, Robin R
– fullname: Boghaert, Erwin R
– fullname: Haight, Anthony R
– fullname: Ackler, Scott L
– fullname: Shen, Xiaoqiang
– fullname: Souers, Andrew J
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Snippet The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Bcl xl inhibitory compounds having low cell permeability and antibody drug conjugates including the same
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