Dihydropyrrolopyridine inhibitors of ROR-gamma

Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) a...

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Main Authors Claremon, David A, Zheng, Yajun, Marcus, Andrew, Yuan, Jing, Dillard, Lawrence Wayne, Singh, Suresh B, Tice, Colin M, Dong, Chengguo, Lotesta, Stephen D, Zhao, Wei, Zhuang, Linghang, Jia, Lanqi, Fan, Yi
Format Patent
LanguageEnglish
Published 06.04.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.
AbstractList Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.
Author Zhao, Wei
Zhuang, Linghang
Singh, Suresh B
Fan, Yi
Lotesta, Stephen D
Dong, Chengguo
Zheng, Yajun
Jia, Lanqi
Claremon, David A
Dillard, Lawrence Wayne
Tice, Colin M
Yuan, Jing
Marcus, Andrew
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– fullname: Zheng, Yajun
– fullname: Marcus, Andrew
– fullname: Yuan, Jing
– fullname: Dillard, Lawrence Wayne
– fullname: Singh, Suresh B
– fullname: Tice, Colin M
– fullname: Dong, Chengguo
– fullname: Lotesta, Stephen D
– fullname: Zhao, Wei
– fullname: Zhuang, Linghang
– fullname: Jia, Lanqi
– fullname: Fan, Yi
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Dihydropyrrolopyridine inhibitors of ROR-gamma
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