Novel salts of DPP-IV inhibitor

H: szp\Interwoven\NRPortbl\DCC\SZP\9225063_1.docx-23/12/2015 NOVEL SALTS OF DPP-IV INHIBITOR The present invention discloses new salts of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6 dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine i.e. gentisate, adipate and trifluoro...

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Main Authors PANDEY, BIPIN, DAVE, MAYANK GHANSHYAMBHAI, KOTHARI, HIMANSHU M, SHUKLA, BHAVIN SHRIPRASAD
Format Patent
LanguageEnglish
Published 21.01.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Abstract H: szp\Interwoven\NRPortbl\DCC\SZP\9225063_1.docx-23/12/2015 NOVEL SALTS OF DPP-IV INHIBITOR The present invention discloses new salts of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6 dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine i.e. gentisate, adipate and trifluoro acetic acid salts. The invention also describes the new crystalline and amorphous forms of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4] triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine gentisate. The present invention also discloses novel crystalline salt form of (2R)-4-oxo-4-[3 (trifluoromethyl)-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5 trifluorophenyl)butan-2-amine hydrochloride and novel crystalline and amorphous salt forms of besylate and process for their preparation and isolation.
AbstractList H: szp\Interwoven\NRPortbl\DCC\SZP\9225063_1.docx-23/12/2015 NOVEL SALTS OF DPP-IV INHIBITOR The present invention discloses new salts of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6 dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine i.e. gentisate, adipate and trifluoro acetic acid salts. The invention also describes the new crystalline and amorphous forms of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4] triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine gentisate. The present invention also discloses novel crystalline salt form of (2R)-4-oxo-4-[3 (trifluoromethyl)-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5 trifluorophenyl)butan-2-amine hydrochloride and novel crystalline and amorphous salt forms of besylate and process for their preparation and isolation.
Author SHUKLA, BHAVIN SHRIPRASAD
PANDEY, BIPIN
DAVE, MAYANK GHANSHYAMBHAI
KOTHARI, HIMANSHU M
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METALLURGY
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Title Novel salts of DPP-IV inhibitor
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