Selectively substituted quinoline compounds

Embodiments of the disclosure relate to selectively substituted quinoline compounds of formula (I) that act as antagonists or inhibitors for Toll -like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis...

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Main Authors BERTINATO, PETER, ISHIZAKA, SALLY, HAWKINS, LYNN, BOIVIN, ROCH, MACKEY, MATTHEW, HANSEN, HANS, SCHILLER, SHAWN, YU, ROBERT T, ENDO, ATSUSHI, OGAWA, CHIKAKO, NARAYAN, SRIDHAR, BERGER, GREGORY
Format Patent
LanguageEnglish
Published 25.02.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Embodiments of the disclosure relate to selectively substituted quinoline compounds of formula (I) that act as antagonists or inhibitors for Toll -like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
Bibliography:Application Number: AU20140334551