Substituted bridged urea analogs as sirtuin modulators

• Main Authors: White, Brian H, Fox, Ryan Michael, Koppetsch, Karsten, Oalmann, Christopher, Caldwell, Richard Dana, Casaubon, Rebecca, Disch, Jeremy S, Blum, Charles A, Ng, Pui Yee, Szczepankiewicz, Bruce G, Perni, Robert B
• Format: Patent
• Language: English
• Published: 06.04.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders...