Inhibitors of beta-secretase

The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACEl) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characte...

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Main Authors Zheng, Yajun, Yuan, Jing, Lala, Deepak S, Cacatian, Salvacion, Zhao, Yi, Dillard, Lawrence Wayne, Singh, Suresh B, Morales-Ramos, Angel, Dorner-Ciossek, Cornelia, Venkatraman, Shankar, Rast, Georg, Xu, Zhenrong, Reeves, Jonathan, Fuchs, Klaus, Jia, Lanqi, Bukhtiyarov, Yuri
Format Patent
LanguageEnglish
Published 05.10.2017
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACEl) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
AbstractList The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACEl) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
Author Rast, Georg
Reeves, Jonathan
Singh, Suresh B
Zhao, Yi
Xu, Zhenrong
Dorner-Ciossek, Cornelia
Morales-Ramos, Angel
Cacatian, Salvacion
Zheng, Yajun
Venkatraman, Shankar
Jia, Lanqi
Bukhtiyarov, Yuri
Dillard, Lawrence Wayne
Yuan, Jing
Lala, Deepak S
Fuchs, Klaus
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– fullname: Singh, Suresh B
– fullname: Morales-Ramos, Angel
– fullname: Dorner-Ciossek, Cornelia
– fullname: Venkatraman, Shankar
– fullname: Rast, Georg
– fullname: Xu, Zhenrong
– fullname: Reeves, Jonathan
– fullname: Fuchs, Klaus
– fullname: Jia, Lanqi
– fullname: Bukhtiyarov, Yuri
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Snippet The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACEl) activity, pharmaceutical compositions...
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SubjectTerms ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Inhibitors of beta-secretase
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