Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives

• Main Authors: PINKSTAFF, JASON, SKIDMORE, LILLIAN, SZYDLIK, AGNIESZKA, BUSS, TIMOTHY, SUN, YING, COOK, MELISSA, VALENTA, IANINA, ATKINSON, KYLE C, KRAYNOV, VADIM, MIAO, ZHENWEI, MARSDEN, ROBIN, BIROC, SANDRA
• Format: Patent
• Language: English
• Published: 09.05.2013
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

[00420] Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least...