Heterocyclic inhibitors of MEK and methods of use thereof

• Main Authors: LYSSIKATOS, JOSEPH P, BOOTH, REBECCA JANE, MARLOW, ALLISON L, SEO, JEONGBEOB, PITTAM, JOHN DAVID, BLAKE, JIM, LEONARD, JOHN, FIELDING, MARK RICHARD, WALLACE, ELI, STOREY, RICHARD ANTHONY, YANG, HONG WOON
• Format: Patent
• Language: English
• Published: 30.08.2012
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions...