Site-directed modification of FVIII

• Main Authors: PAN, CLARK Q, MURPHY, JOHN E, STRAUSS, JONATHAN S, TJANDRA, HENDRI, MEI, BAISONG, BARNETT, THOMAS, CHEN, JIANMIN, WANG, DEQIAN, TANG, LIANG
• Format: Patent
• Language: English
• Published: 24.10.2013
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; DERIVATIVES THEREOF; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; SPIRITS; SUGARS; VINEGAR; WINE

C:\NRPortb\DCCKXC\4427591 - DOC.2(16/21112 This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and ha...