Process for the preparation of isoxazoline derivatives

The present invention relates to processes for the preparation of compounds of formula IB wherein A, A, A, A, L, Y, Y, R, R, R, R and R are as defined in the claims, comprising reacting a compound of formula (II) wherein Y, Y, L, A, A, R, R, R, R and R are as defined for the compound of formula (I);...

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Main Authors MULHOLLAND, NICHOLAS PHILLIP, RENOLD, PETER, GODINEAU, EDOUARD, REVOL, GUILLAUME, CASSAYRE, JEROME YVES, EL QACEMI, MYRIEM
Format Patent
LanguageEnglish
Published 23.08.2012
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Summary:The present invention relates to processes for the preparation of compounds of formula IB wherein A, A, A, A, L, Y, Y, R, R, R, R and R are as defined in the claims, comprising reacting a compound of formula (II) wherein Y, Y, L, A, A, R, R, R, R and R are as defined for the compound of formula (I); with hydroxylamine in the presence of water, a base and a chiral phase transfer catalyst, which chiral phase transfer catalyst is a quinine derivative. The invention also relates to compounds of formula IB and enantiomerically enriched mixtures comprising compounds of formula IB.
Bibliography:Application Number: AU20110220041