Salt form of a multi-arm polymer-drug conjugate

Among other aspects, provided herein is a hydrohalide salt of a multi-arm water- soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the correspondi...

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Main Authors SPENCE, PATRICK, MCMANUS, SAMUEL, HANDLEY, JOHN, JOSHI, BHALCHANDRA V, KOZLOWSKI, ANTONI, LAVATY, GREG, TIPNIS, SACHIN, BRAY, BRIAN, NIE, SHAOYONG, SCHAEFER, ANTHONY, CHONG, ANTHONY O, LEE, SEOJU, SWALLOW, DAVID
Format Patent
LanguageEnglish
Published 14.01.2016
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Among other aspects, provided herein is a hydrohalide salt of a multi-arm water- soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding free base form of the conjugate.
Bibliography:Application Number: AU20100321882