Anti-mesothelin immunoconjugates and uses therefor

• Main Authors: KOPITZ, CHARLOTTE CHRISTINE, HEISLER, IRING, BERHORSTER, KERSTIN, SCHUMACHER, JOACHIM
• Format: Patent
• Language: English
• Published: 10.11.2011
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co- administered or formulated with one or more additional ant...