Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors

• Main Authors: COOK, CAROLINE MARY, JOHNSON, MARTIN REDPATH, COOPER, ANTHONY WILLIAM JAMES, ALLEN, DAVID GEORGE, MITCHELL, CHARLOTTE JANE, HAMBLIN, JULIE NICOLE, REDGRAVE, ALISON JUDITH, EDLIN, CHRISTOPHER DAVID, COE, DIANE MARY, LINDVALL, MIKA KRISTIAN, DOWLE, MICHAEL DENNIS, JONES, PAUL SPENCER
• Format: Patent
• Language: English
• Published: 30.08.2012
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Abstract The invention relates to a compound of formula (I) or a salt thereof: Formula (I) wherein: R1 is C .4alkyl, C1.3fluoroalkyl or -(CH 2)20H; R2 is a hydrogen atom (H), methyl or Cifluoroalkyl; R3a is a hydrogen atom (H) or C1.3alkyl; R3 is optionally substituted 5 branched C3 .6 alkyl, option...