Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors
Abstract The invention relates to a compound of formula (I) or a salt thereof: Formula (I) wherein: R1 is C .4alkyl, C1.3fluoroalkyl or -(CH 2)20H; R2 is a hydrogen atom (H), methyl or Cifluoroalkyl; R3a is a hydrogen atom (H) or C1.3alkyl; R3 is optionally substituted 5 branched C3 .6 alkyl, option...
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Format | Patent |
Language | English |
Published |
30.08.2012
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Abstract | Abstract The invention relates to a compound of formula (I) or a salt thereof: Formula (I) wherein: R1 is C .4alkyl, C1.3fluoroalkyl or -(CH 2)20H; R2 is a hydrogen atom (H), methyl or Cifluoroalkyl; R3a is a hydrogen atom (H) or C1.3alkyl; R3 is optionally substituted 5 branched C3 .6 alkyl, optionally substituted C3.scycloalkyl, optionally substituted mono unsaturated-C 5.7cycloalkenyl, optionally substituted phenyl, or an optionally substituted heterocyclic group of sub-formula (aa), or (bb) or (cc) in which nI and n2 independently are I or 2; and Y is 0, S, SO 2 , or NR4, and wherein Het is of sub-formula (i), or (ii), or (iii), or (iv) or (v). The compounds are phosphodiesterase (PDE) inhibitors, in particular 10 PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis. |
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AbstractList | Abstract The invention relates to a compound of formula (I) or a salt thereof: Formula (I) wherein: R1 is C .4alkyl, C1.3fluoroalkyl or -(CH 2)20H; R2 is a hydrogen atom (H), methyl or Cifluoroalkyl; R3a is a hydrogen atom (H) or C1.3alkyl; R3 is optionally substituted 5 branched C3 .6 alkyl, optionally substituted C3.scycloalkyl, optionally substituted mono unsaturated-C 5.7cycloalkenyl, optionally substituted phenyl, or an optionally substituted heterocyclic group of sub-formula (aa), or (bb) or (cc) in which nI and n2 independently are I or 2; and Y is 0, S, SO 2 , or NR4, and wherein Het is of sub-formula (i), or (ii), or (iii), or (iv) or (v). The compounds are phosphodiesterase (PDE) inhibitors, in particular 10 PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis. |
Author | HAMBLIN, JULIE NICOLE LINDVALL, MIKA KRISTIAN ALLEN, DAVID GEORGE REDGRAVE, ALISON JUDITH COOK, CAROLINE MARY EDLIN, CHRISTOPHER DAVID DOWLE, MICHAEL DENNIS JOHNSON, MARTIN REDPATH MITCHELL, CHARLOTTE JANE COOPER, ANTHONY WILLIAM JAMES COE, DIANE MARY JONES, PAUL SPENCER |
Author_xml | – fullname: COOK, CAROLINE MARY – fullname: JOHNSON, MARTIN REDPATH – fullname: COOPER, ANTHONY WILLIAM JAMES – fullname: ALLEN, DAVID GEORGE – fullname: MITCHELL, CHARLOTTE JANE – fullname: HAMBLIN, JULIE NICOLE – fullname: REDGRAVE, ALISON JUDITH – fullname: EDLIN, CHRISTOPHER DAVID – fullname: COE, DIANE MARY – fullname: LINDVALL, MIKA KRISTIAN – fullname: DOWLE, MICHAEL DENNIS – fullname: JONES, PAUL SPENCER |
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Snippet | Abstract The invention relates to a compound of formula (I) or a salt thereof: Formula (I) wherein: R1 is C .4alkyl, C1.3fluoroalkyl or -(CH 2)20H; R2 is a... |
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Title | Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors |
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