Agonists of toll-like receptor 5 for the treatment of graft-versus-host disease

• Main Authors: GEWITZ, ANDREW T, ROBACK, JOHN D, WALLER, EDMUND K, HOSSAIN, MOHAMMAD S
• Format: Patent
• Language: English
• Published: 15.01.2015
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide,...