Isoprene synthase variants for improved microbial production of isoprene

The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosy...

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Main Authors MIASNIKOV, ANDREI, BOTT, RICHARD R, KELLIS, JAMES, CERVIN, MARGUERITE A, WHITED, GREGORY M, MCAULIFFE, JOSEPH, WELLS, DEREK H, PERES, CAROLINE M, WEYLER, WALTER, RIFE, CHRISTOPHER
Format Patent
LanguageEnglish
Published 05.09.2013
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Abstract The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
AbstractList The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
Author CERVIN, MARGUERITE A
WHITED, GREGORY M
WELLS, DEREK H
PERES, CAROLINE M
WEYLER, WALTER
MIASNIKOV, ANDREI
KELLIS, JAMES
BOTT, RICHARD R
RIFE, CHRISTOPHER
MCAULIFFE, JOSEPH
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– fullname: MCAULIFFE, JOSEPH
– fullname: WELLS, DEREK H
– fullname: PERES, CAROLINE M
– fullname: WEYLER, WALTER
– fullname: RIFE, CHRISTOPHER
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THE GOODYEAR TIRE & RUBBER COMPANY
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Snippet The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In...
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SubjectTerms BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
Title Isoprene synthase variants for improved microbial production of isoprene
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