Pyridinone and pyridazinone derivatives as inhibitors of poly(ADP-ribose)polymerase (PARP)

• Main Authors: KINZEL, OLAF, FERRIGNO, FEDERICA, PESCATORE, GIOVANNA, JONES, PHILIP, LLAUGER BUFI, LAURA, SCHULTZ-FADEMRECHT, CARSTEN
• Format: Patent
• Language: English
• Published: 26.09.2013
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, rena...