5-substituted-2-phenylamino-benzamide as MEK inhibitor

An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically accepta...

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Main Authors TAKESHI MURATA, SHINJI TSUJII, MASANORI MIWA, YASUAKI MATSUBARA, NOBUO SHIMMA, YOSHIAKI ISSHIKI, YASUNORI KOHCHI, EISAKU MIZUGUCHI, MASAMI KOHCHI, SATOSHI AIDA, HITOSHI IIKURA, KOSUKE ASO
Format Patent
LanguageEnglish
Published 02.02.2006
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R 1 , R 2 , R 3 , R 4 , and X are the same as defined in the present patent application].
Bibliography:Application Number: AU20050265769