Mitotic kinesin inhibitor
A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein R 1 represents a hydrogen atom and the like, R 2 represents a hydrogen atom, -C(=W)R 6 (wherein W represe...
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Main Authors | , , , , , , |
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Format | Patent |
Language | English |
Published |
18.03.2010
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Subjects | |
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Abstract | A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient:
[wherein R 1 represents a hydrogen atom and the like, R 2 represents a hydrogen atom, -C(=W)R 6 (wherein W represents an oxygen atom or a sulfur atom, and R 6 represents substituted or unsubstituted lower alkyl and the like) and the like, R 3 represents -C(=Z)R 19 (wherein Z represents an oxygen atom or a sulfur atom, and R 19 represents substituted or unsubstituted lower alkyl and the like) and the like, R 4 represents substituted or unsubstituted lower alkyl and the like, and R 5 represents substituted or unsubstituted aryl and the like] and the like are provided. |
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AbstractList | A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient:
[wherein R 1 represents a hydrogen atom and the like, R 2 represents a hydrogen atom, -C(=W)R 6 (wherein W represents an oxygen atom or a sulfur atom, and R 6 represents substituted or unsubstituted lower alkyl and the like) and the like, R 3 represents -C(=Z)R 19 (wherein Z represents an oxygen atom or a sulfur atom, and R 19 represents substituted or unsubstituted lower alkyl and the like) and the like, R 4 represents substituted or unsubstituted lower alkyl and the like, and R 5 represents substituted or unsubstituted aryl and the like] and the like are provided. |
Author | YOJI INO RYUICHIRO NAKAI YOSHINORI YAMASHITA CHIKARA MURAKATA KAZUHITO AKASAKA YUSHI KITAMURA KAZUHIKO KATO |
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RelatedCompanies | FUJIFILM CORPORATION KYOWA HAKKO KIRIN CO., LTD |
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Snippet | A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt... |
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Title | Mitotic kinesin inhibitor |
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