ANTI-RETROVIRAL 5,6-DISUBSTITUTED ACYCLOPYRIMIDINE NUCLEOSIDE DERIVATIVES

The present invention provides novel pyrimidine nucleoside derivatives represented by the following formula (I): HN I R2 CH (CH2)n 2,X 1 SIMILAR D3 wherein R represents e.g. an alkyl group; RZ represents e.g. a phenyl group or a 3,5-dimethylphenyl group; and R represents e.g. a vinyl group or a ethy...

Full description

Saved in:
Bibliographic Details
Main Authors ANNE MARIE BOEL, BENT FABER VESTERGAARD, NASSER R. EL-BROLLOSY, BERIT DAHAN, ERIK BJERREGAARD PEDERSEN, CLAUS NIELSEN, PER TROLLE JORGENSEN
Format Patent
LanguageEnglish
Published 24.07.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The present invention provides novel pyrimidine nucleoside derivatives represented by the following formula (I): HN I R2 CH (CH2)n 2,X 1 SIMILAR D3 wherein R represents e.g. an alkyl group; RZ represents e.g. a phenyl group or a 3,5-dimethylphenyl group; and R represents e.g. a vinyl group or a ethynyl group; A, B and X represent e.g. oxygene atoms; Z represents e.g. a methylene group or a carbonyl group; n is e.g. 1. The compounds were found to be highly active against wild-type and mutant HIV-1.
Bibliography:Application Number: AU20030205536