Crystalline forms of ertapenem sodium

• Main Authors: ROBERT M. WENSLOW, LOUIS S. CROCKER, JOHN M. WILLIAMS, RONALD JOBSON, AMAR J. MAHAJAN, KAREL M. J. BRANDS, MICHAEL D. WARD, DANIEL R. SIDLER, CHARLES ORELLA, RAYMOND CVETOVICH, ELIZABETH S. FISHER
• Format: Patent
• Language: English
• Published: 26.07.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containin...