Crystalline forms of ertapenem sodium
A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containin...
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| Main Authors | , , , , , , , , , , |
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| Format | Patent |
| Language | English |
| Published |
26.07.2007
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| Online Access | Get full text |
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| Abstract | A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between -5 and -25° C. |
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| AbstractList | A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between -5 and -25° C. |
| Author | JOHN M. WILLIAMS ROBERT M. WENSLOW ELIZABETH S. FISHER CHARLES ORELLA KAREL M. J. BRANDS RAYMOND CVETOVICH DANIEL R. SIDLER RONALD JOBSON LOUIS S. CROCKER AMAR J. MAHAJAN MICHAEL D. WARD |
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| Snippet | A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to... |
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| Title | Crystalline forms of ertapenem sodium |
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