Crystalline forms of ertapenem sodium

A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containin...

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Main Authors ROBERT M. WENSLOW, LOUIS S. CROCKER, JOHN M. WILLIAMS, RONALD JOBSON, AMAR J. MAHAJAN, KAREL M. J. BRANDS, MICHAEL D. WARD, DANIEL R. SIDLER, CHARLES ORELLA, RAYMOND CVETOVICH, ELIZABETH S. FISHER
Format Patent
LanguageEnglish
Published 26.07.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between -5 and -25° C.
Bibliography:Application Number: AU20020331885