Process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo(1,2-A)pyrimidine-3- (N,N-dimethyl-acetamide) and intermediates

The invention relates to a new and improved process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidine-3-(N,N-dimethyl-acetamide) of Formula (I) and pharmaceutically acceptable acid addition salts thereof which comprises reacting an ester of general Formula (II) (wherein R...

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Main Authors LASZLO KONCZ, LASZLO PONGO, GYULA SIMIG, KALMAN NAGY, PETER TOMPE, JOZSEF REITER, ENDRE RIVO, GYORGYI VERECZKEYNE DONATH, VALERIA HOFFMANNE FEKETE
Format Patent
LanguageEnglish
Published 04.06.2001
Edition7
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Abstract The invention relates to a new and improved process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidine-3-(N,N-dimethyl-acetamide) of Formula (I) and pharmaceutically acceptable acid addition salts thereof which comprises reacting an ester of general Formula (II) (wherein R is lower alkyl or phenyl-lower alkyl) in a polar protic or aprotic solvent with dimethyl amine and, if desired, converting the compound of the Formula (I) thus obtained into a pharmaceutically acceptable acid addition salt. The compound of Formula I is a known valuable sedative used in therapy. The invention also relates to new intermediates of general Formula (II) (wherein R is lower alkyl or phenyl-lower alkyl) useful in the process.
AbstractList The invention relates to a new and improved process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidine-3-(N,N-dimethyl-acetamide) of Formula (I) and pharmaceutically acceptable acid addition salts thereof which comprises reacting an ester of general Formula (II) (wherein R is lower alkyl or phenyl-lower alkyl) in a polar protic or aprotic solvent with dimethyl amine and, if desired, converting the compound of the Formula (I) thus obtained into a pharmaceutically acceptable acid addition salt. The compound of Formula I is a known valuable sedative used in therapy. The invention also relates to new intermediates of general Formula (II) (wherein R is lower alkyl or phenyl-lower alkyl) useful in the process.
Author GYULA SIMIG
VALERIA HOFFMANNE FEKETE
LASZLO KONCZ
PETER TOMPE
KALMAN NAGY
ENDRE RIVO
GYORGYI VERECZKEYNE DONATH
LASZLO PONGO
JOZSEF REITER
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– fullname: JOZSEF REITER
– fullname: ENDRE RIVO
– fullname: GYORGYI VERECZKEYNE DONATH
– fullname: VALERIA HOFFMANNE FEKETE
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Snippet The invention relates to a new and improved process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidine-3-(N,N-dimethyl-acetamide) of...
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Title Process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo(1,2-A)pyrimidine-3- (N,N-dimethyl-acetamide) and intermediates
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