AMIDE ALS PYRUVATDEHYDROGENASEINHIBITOREN

• Main Authors: PEASE, JANET, NOWAK, THORSTEN, CLARKE, DAVID, BLOCK, MICHAEL, BUTLIN, ROGER, BURROWS, JEREMY
• Format: Patent
• Language: German
• Published: 15.07.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A compound of formula (I):wherein:Ring A is a nitrogen linked mono or bicyclic heterocyclic ring as defined within;R and R are independently C1-3alkyl optionally substituted by fluoro or chloro;or R and R together with the carbon atom to which they are attached, form a C3-5cycloalkyl ring optionally substituted by fluoro;R is defined within; andn is 0-5; wherein the values of R may be the same or different;or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.