AMIDE ALS PYRUVATDEHYDROGENASEINHIBITOREN

A compound of formula (I):wherein:Ring A is a nitrogen linked mono or bicyclic heterocyclic ring as defined within;R and R are independently C1-3alkyl optionally substituted by fluoro or chloro;or R and R together with the carbon atom to which they are attached, form a C3-5cycloalkyl ring optionally...

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Bibliographic Details
Main Authors PEASE, JANET, NOWAK, THORSTEN, CLARKE, DAVID, BLOCK, MICHAEL, BUTLIN, ROGER, BURROWS, JEREMY
Format Patent
LanguageGerman
Published 15.07.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound of formula (I):wherein:Ring A is a nitrogen linked mono or bicyclic heterocyclic ring as defined within;R and R are independently C1-3alkyl optionally substituted by fluoro or chloro;or R and R together with the carbon atom to which they are attached, form a C3-5cycloalkyl ring optionally substituted by fluoro;R is defined within; andn is 0-5; wherein the values of R may be the same or different;or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.
Bibliography:Application Number: AT20000954797T