STABILE, NICHT-HYGROSKOPISCHE, KRISTALLINE FORM VON N-ÄN-N(4-(PIPERIDIN-4-YL)BUTANOYL)-N- ETHYLGLYCYL VERBINDUNGEN

The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)- beta -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof,...

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Main Authors LIU, ROBERT, VEMURI, NARASIMHA, WINDISCH, VINCENT, WOODWARD, RICK, MENCEL, JAMES, KUBIAK, GREGORY, VANASSE, BENOIT, CHRZAN, ZOFIA, GARDETTO, ANTHONY, SHERBINE, JAMES, TOLEDO-VELASQUEZ, DAVID, RODRIGUEZ, WALTER, POWERS, MATTHEW, SALAZAR, DIANE, SLEDESKI, ADAM
Format Patent
LanguageGerman
Published 15.04.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)- beta -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula wherein: A, B, Z, E1, E2, G, R, m, n, and p are as defined herein.
AbstractList The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)- beta -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula wherein: A, B, Z, E1, E2, G, R, m, n, and p are as defined herein.
Author WOODWARD, RICK
LIU, ROBERT
MENCEL, JAMES
RODRIGUEZ, WALTER
SLEDESKI, ADAM
VEMURI, NARASIMHA
VANASSE, BENOIT
SALAZAR, DIANE
CHRZAN, ZOFIA
GARDETTO, ANTHONY
POWERS, MATTHEW
WINDISCH, VINCENT
TOLEDO-VELASQUEZ, DAVID
KUBIAK, GREGORY
SHERBINE, JAMES
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– fullname: WOODWARD, RICK
– fullname: MENCEL, JAMES
– fullname: KUBIAK, GREGORY
– fullname: VANASSE, BENOIT
– fullname: CHRZAN, ZOFIA
– fullname: GARDETTO, ANTHONY
– fullname: SHERBINE, JAMES
– fullname: TOLEDO-VELASQUEZ, DAVID
– fullname: RODRIGUEZ, WALTER
– fullname: POWERS, MATTHEW
– fullname: SALAZAR, DIANE
– fullname: SLEDESKI, ADAM
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Snippet The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title STABILE, NICHT-HYGROSKOPISCHE, KRISTALLINE FORM VON N-ÄN-N(4-(PIPERIDIN-4-YL)BUTANOYL)-N- ETHYLGLYCYL VERBINDUNGEN
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