STABILE, NICHT-HYGROSKOPISCHE, KRISTALLINE FORM VON N-ÄN-N(4-(PIPERIDIN-4-YL)BUTANOYL)-N- ETHYLGLYCYL VERBINDUNGEN

The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)- beta -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof,...

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Main Authors LIU, ROBERT, VEMURI, NARASIMHA, WINDISCH, VINCENT, WOODWARD, RICK, MENCEL, JAMES, KUBIAK, GREGORY, VANASSE, BENOIT, CHRZAN, ZOFIA, GARDETTO, ANTHONY, SHERBINE, JAMES, TOLEDO-VELASQUEZ, DAVID, RODRIGUEZ, WALTER, POWERS, MATTHEW, SALAZAR, DIANE, SLEDESKI, ADAM
Format Patent
LanguageGerman
Published 15.04.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)- beta -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula wherein: A, B, Z, E1, E2, G, R, m, n, and p are as defined herein.
Bibliography:Application Number: AT19970939488T