BENZENESULFONAMID-DERIVATIVE UND IHRE VERWENDUNG ALS MEK-INHIBITOREN

Benzenesulfonamides of formula (I), in which W is OR1, NR2OR1, NRARB, NR2NRARB , or NR2(CH2)2-4NRARB and the other variables as defined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cy...

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Bibliographic Details
Main Authors TECLE, HAILE, BARRETT, STEPHEN, DOUGLAS, BOOTH, RICHARD, JOHN
Format Patent
LanguageGerman
Published 15.11.2005
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Benzenesulfonamides of formula (I), in which W is OR1, NR2OR1, NRARB, NR2NRARB , or NR2(CH2)2-4NRARB and the other variables as defined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cystic fibrosis, hepatomegaly, cardiomegaly, Alzheimer's disease, complications of diabetes, septic shock, and viral infection.
Bibliography:Application Number: AT19990966496T