VERFAHREN ZUR ENZYMATISCHEN ENANTIOMEREN-TRENNUNG VON RAC-2-OXOTRICYCLO 2,2,1,03,5 -HEPTAN-7- CARBONSÄURE BZW. DER -CARBONSÄUREESTER

Process for enzymic resolution (racemate or enantiomer sepn.) of enantiomer or racemic mixts. of oxo-tricyclo-heptane carboxylate cpds. of formula (I) comprises: (a) treating (I) with an enzyme (A) in water and opt. cosolvent and (b) sepg. acid and ester. (A) is a lipase or esterase derived from por...

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Main Authors HOLLA, WOLFGANG, BECK, GERHARD
Format Patent
LanguageGerman
Published 15.03.2005
Edition7
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Abstract Process for enzymic resolution (racemate or enantiomer sepn.) of enantiomer or racemic mixts. of oxo-tricyclo-heptane carboxylate cpds. of formula (I) comprises: (a) treating (I) with an enzyme (A) in water and opt. cosolvent and (b) sepg. acid and ester. (A) is a lipase or esterase derived from porcine liver, porcine or bovine pancreas, or from microorganisms such as Candida, Pseudomonas, Mucor, Rhizopus and Aspergillus or a protease from Bacillus. R1 = 1-10C alkyl, 3-10C cycloalkyl, 2-10C alkenyl, 2-10C alkinyl, 3-8C cycloalkenyl (all opt. mono- to tri-substd., by F, Cl, Br, I, CN, COOR, CONH2, R R , NO2, OR, OCOOR, SPh, SMe, SEt, SO2Ph, SO2R, aryl, heteroaryl) or alkyl and alkenyl gps. with 3-10C atoms or alkinyl gps. with 4-10C atoms, 5-10C aryl or 5-10C heteroaryl or N=CR4R5 or C(R6)=CR7R8 or COR9; R = 1-4C alkyl; R2,R3 = H, 1-6C alkyl, 3-10C cycloalkyl, 2-6C alkenyl, 2-6C alkinyl, phenyl, benzyl, benzoyl, or amino-protection gp,; R4,R5 = H or 1-6C alkyl or R4+R5 = alkylene or alkenylene; R6-R8 = H, Me or Et and R9 = H, alkyl or 2-oxo-tricyclo Ä2,2,1,0<3.5>Ühepta-7-carbonyl.
AbstractList Process for enzymic resolution (racemate or enantiomer sepn.) of enantiomer or racemic mixts. of oxo-tricyclo-heptane carboxylate cpds. of formula (I) comprises: (a) treating (I) with an enzyme (A) in water and opt. cosolvent and (b) sepg. acid and ester. (A) is a lipase or esterase derived from porcine liver, porcine or bovine pancreas, or from microorganisms such as Candida, Pseudomonas, Mucor, Rhizopus and Aspergillus or a protease from Bacillus. R1 = 1-10C alkyl, 3-10C cycloalkyl, 2-10C alkenyl, 2-10C alkinyl, 3-8C cycloalkenyl (all opt. mono- to tri-substd., by F, Cl, Br, I, CN, COOR, CONH2, R R , NO2, OR, OCOOR, SPh, SMe, SEt, SO2Ph, SO2R, aryl, heteroaryl) or alkyl and alkenyl gps. with 3-10C atoms or alkinyl gps. with 4-10C atoms, 5-10C aryl or 5-10C heteroaryl or N=CR4R5 or C(R6)=CR7R8 or COR9; R = 1-4C alkyl; R2,R3 = H, 1-6C alkyl, 3-10C cycloalkyl, 2-6C alkenyl, 2-6C alkinyl, phenyl, benzyl, benzoyl, or amino-protection gp,; R4,R5 = H or 1-6C alkyl or R4+R5 = alkylene or alkenylene; R6-R8 = H, Me or Et and R9 = H, alkyl or 2-oxo-tricyclo Ä2,2,1,0<3.5>Ühepta-7-carbonyl.
Author HOLLA, WOLFGANG
BECK, GERHARD
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Snippet Process for enzymic resolution (racemate or enantiomer sepn.) of enantiomer or racemic mixts. of oxo-tricyclo-heptane carboxylate cpds. of formula (I)...
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SourceType Open Access Repository
SubjectTerms ACYCLIC OR CARBOCYCLIC COMPOUNDS
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PROCESSES USING MICROORGANISMS
SPIRITS
VINEGAR
WINE
Title VERFAHREN ZUR ENZYMATISCHEN ENANTIOMEREN-TRENNUNG VON RAC-2-OXOTRICYCLO 2,2,1,03,5 -HEPTAN-7- CARBONSÄURE BZW. DER -CARBONSÄUREESTER
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