VERFAHREN ZUR ISOLIERUNG UND REINIGUNG VON MEVINOLIN

• Main Authors: DEAK LAJOS, JAKAB ATTILA, MATYAS SZABOLCS, BAGDI ILONA, ILKOEY EVA, AMBRUS GABOR, KOVACS VERA, SZABO ISTVAN, HORVATH GYULA, LANG ILDIKO, MORAVCSIK IMRE, ANDOR ATTILA, SZABO CSABA, HOEGYE IRMA, BALINT JANOS, SCHEIDL ZSUZSANNA, KERI VILMOS, SZEKELY IMRE, JEKKEL ANTONIA, DELI ETELKA, SZTARAY ZSUZSANNA, ESZENYI LASZLO
• Format: Patent
• Language: German
• Published: 15.10.1995
• Edition: 6
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; SPIRITS; VINEGAR; WINE

The present invention relates to a process for the isolation of mevinolin by dissolving the active ingredient from the biomass into the fermentation liquor and subsequently separating it from the filtered fermentation liquor, which comprises carrying out the dissolution at a pH value between 7.5 and 10.0, preferably between 8.0 and 9.0, separating the active ingredient from the filtered liquor at a pH value between 4.5 and 1.0, preferably between 2.2 and 2.0, filtering and purifying it by methods known per se, preferably by recrystallization.