VERFAHREN ZUR HERSTELLUNG VON NEUEN 3,4-DIHYDRO-5H-2,3-BENZODIAZEPINDERIVATEN SOWIE VON DEREN SAEUREADDITIONSSALZEN

• Main Authors: ANDRASI FERENC DR, BALOGH TIBOR DR, LANG TIBOR DR, KOEROESI JENOE DR, HAMORI TAMAS, GOLDSCHMIDT KATALIN DR, ILA LAJOS, MORAVCSIK IMRE, SZEKELY JOZSEF DR, SINEGER ELEONORA DR
• Format: Patent
• Language: German
• Published: 25.05.1987
• Edition: 4
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to new 3,4-dihydro-5H-2,3-benzodiazepine derivatives of general formula (I) and pharmaceutically acceptable acid addition salts thereof, (I) wherein R represents a phenyl group optionally carrying one or two substituents selected from the group consisting of halogen, hydroxy, C1-4 alkoxy and benzyloxy; a furyl or a thienyl group, R1 stands for a hydrogen atom or a C1-4 alkyl group, R2 and R3 each represent hydrogen atom, C1-4 alkoxy, C4-7 cycloalkoxy or benzyloxy group. The new compounds of the general formula (I) can be prepared by reducing a 5H-2,3-benzodiazepine derivative of the general formula (II) (II) wherein R, R1, R2 and R3 have the above-defined meanings, with an inorganic or organic hydride and/or complex metal hydride. The new compounds of the general formula (I) possess significant central nervous effects and can advantageously be used in the therapy.