Characterization of Immortalized Osteoclast Precursors Developed from Mice Transgenic for Both bcl-XL and Simian Virus 40 Large T Antigen1

• Published in: Endocrinology (Philadelphia) Vol. 140; no. 7; pp. 2954 - 2961
• Main Authors: Hentunen, Teuvo A, Jackson, Sharon H, Chung, Hoyeon, Reddy, Sakamuri V, Lorenzo, Joseph, Choi, Sun Jin, Roodman, G. David
• Format: Journal Article
• Language: English
• Published: Endocrine Society 01.07.1999

We recently developed an immortalized osteoclast (OCL) precursor cell line that forms large numbers of OCLs. This cell line was derived from mice doubly transgenic for bcl-XL and large T antigen that was targeted to cells in the OCL lineage (bcl-XL/Tag cells). We have now characterized these cells i...