The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque

Atherosclerosis is a condition in which a lipid deposition, thrombus formation, immune cell infiltration, and a chronic inflammatory response, but its systemic study has been hampered by the lack of suitable animal models, especially in herbalism fields. We have tried to perform a perfect animal mod...

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Published inBioMed research international Vol. 2012; no. 2012; pp. 1 - 11
Main Authors Zhang, Junping, Yang, Cui, Li, Peng, Xu, Yingzhi, Li, Liangjun, Li, Ming, Zhang, Guangyin, Zhou, Yanan
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2012
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Abstract Atherosclerosis is a condition in which a lipid deposition, thrombus formation, immune cell infiltration, and a chronic inflammatory response, but its systemic study has been hampered by the lack of suitable animal models, especially in herbalism fields. We have tried to perform a perfect animal model that completely replicates the stages of human atherosclerosis. This is the first combined study about the immunologic injury and balloon injury based on the cholesterol diet. In this study, we developed a modified protocol of the white rabbit model that could represent a novel approach to studying human atherosclerosis and vulnerable plaque.
AbstractList Atherosclerosis is a condition in which a lipid deposition, thrombus formation, immune cell infiltration, and a chronic inflammatory response, but its systemic study has been hampered by the lack of suitable animal models, especially in herbalism fields. We have tried to perform a perfect animal model that completely replicates the stages of human atherosclerosis. This is the first combined study about the immunologic injury and balloon injury based on the cholesterol diet. In this study, we developed a modified protocol of the white rabbit model that could represent a novel approach to studying human atherosclerosis and vulnerable plaque.
Author Li, Ming
Li, Liangjun
Zhang, Junping
Zhang, Guangyin
Zhou, Yanan
Yang, Cui
Li, Peng
Xu, Yingzhi
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