Evaluation of Epstein-Barr Virus Latent Membrane Protein 2 Specific T-Cell Receptors Driven by T-Cell Specific Promoters Using Lentiviral Vector

• Published in: Journal of immunology research Vol. 2011; no. 2011; pp. 1 - 10
• Main Authors: Sun, Beicheng, Chen, Yun, Hou, Jiajie, Jiang, Runqiu, Gao, Yun, Mu, Xiaoxin, Sun, Hua, Shao, Qing, Yang, Dongchang, Yao, Kun
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2010

Transduction of latent membrane protein 2 (LMP2)-specific T-cell receptors into activated T lymphocytes may provide a universal, MHC-restricted mean to treat EBV-associated tumors in adoptive immunotherapy. We compared TCR-specific promoters of distinct origin in lentiviral vectors, that is, Vβ6.7,...