trans Palmitoleic acid arises endogenously from dietary vaccenic acid123
trans Palmitoleic acid (t-16:1n–7, or 16:1t9 in the δ nomenclature usually applied to trans fatty acids and used herein) arouses great scientific interest because it has been suggested to serve as a biomarker for lower risks of type 2 diabetes and coronary artery disease. Although 16:1t9 has been as...
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Published in | The American journal of clinical nutrition Vol. 99; no. 3; pp. 431 - 435 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Inc
01.03.2014
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Online Access | Get full text |
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Summary: | trans Palmitoleic acid (t-16:1n–7, or 16:1t9 in the δ nomenclature usually applied to trans fatty acids and used herein) arouses great scientific interest because it has been suggested to serve as a biomarker for lower risks of type 2 diabetes and coronary artery disease.
Although 16:1t9 has been assumed to derive from dietary sources, we examined the hypothesis that 16:1t9 might also be endogenously produced from its metabolic precursor vaccenic acid (t-18:1n–7 or 18:1t11).
We reevaluated fatty acid data obtained from one human intervention study and one cellular model in both of which 18:1t11 was supplemented. Both studies have already been published, but to our knowledge, 16:1t9 has not yet been considered. This reanalysis of the datasets was reasonable because a new methodology for identifying 16:1 cis and trans isomers allowed us to address the subject presented in this article.
Data showed that the systemic or intracellular increase in 16:1t9 was strongly correlated with the increase in 18:1t11 after the dietary intake or cellular uptake of 18:1t11. The conversion rate in humans was, on average, 17%.
Our findings suggest that endogenous 16:1t9 is not, as has been assumed, exclusively diet derived but may also be produced by the partial β oxidation of dietary 18:1t11. |
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ISSN: | 0002-9165 1938-3207 |
DOI: | 10.3945/ajcn.113.076117 |