Effect of Ascorbic Acid Deprivation in Guinea Pigs on Skeletal Metabolism1
The skeletal response to ascorbic acid deficiency in guinea pigs was studied. A reduction in skeletal deposition of both radioactive calcium and phosphorus was consistently observed following 14 days of vitamin C deprivation; and the lability of deposited bone salts was increased in the deficient an...
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| Published in | The Journal of nutrition Vol. 95; no. 3; pp. 388 - 392 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Inc
01.07.1968
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| Online Access | Get full text |
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| Abstract | The skeletal response to ascorbic acid deficiency in guinea pigs was studied. A reduction in skeletal deposition of both radioactive calcium and phosphorus was consistently observed following 14 days of vitamin C deprivation; and the lability of deposited bone salts was increased in the deficient animals. Subsequent calculations showed a highly significant inverse relationship between these parameters. Development of each was dependent on the time of deficiency. The close relationship between deposition and bone salt release leads to the suggestion that the type and amount of matrix formed was altered by the ascorbic acid deficiency. It is suggested that ascorbate deprivation, similar to that of some other deficiencies, may impede the transition of amorphic bone salts to the crystalline form. |
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| AbstractList | The skeletal response to ascorbic acid deficiency in guinea pigs was studied. A reduction in skeletal deposition of both radioactive calcium and phosphorus was consistently observed following 14 days of vitamin C deprivation; and the lability of deposited bone salts was increased in the deficient animals. Subsequent calculations showed a highly significant inverse relationship between these parameters. Development of each was dependent on the time of deficiency. The close relationship between deposition and bone salt release leads to the suggestion that the type and amount of matrix formed was altered by the ascorbic acid deficiency. It is suggested that ascorbate deprivation, similar to that of some other deficiencies, may impede the transition of amorphic bone salts to the crystalline form. |
| Author | Thornton, Paul A. |
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| ContentType | Journal Article |
| Copyright | 1968 American Institute of Nutrition. |
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| DOI | 10.1093/jn/95.3.388 |
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| Discipline | Diet & Clinical Nutrition |
| EndPage | 392 |
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| References | Peterkofsky, Udenfriend (bib4) 1965; 53 Bourne (bib6) 1942; 31 Manoussos, Milhaud (bib11) 1958; 247 Thornton, Omdahl (bib8) 1966 Harper, Posner (bib16) 1966; 122 Friberg, Ringertz (bib7) 1954; 6 Bourne (bib1) 1956 Neuman, Firschein, Chem, Mulryan, Distefano (bib13) 1956; 78 Hess (bib15) 1920 Termine, Posner (bib17) 1967; 1 Pucher, Sherman, Vickery (bib9) 1936; 1113 Snedecor (bib12) 1956 Gould, Woessner (bib2) 1957; 266 Bourne (bib5) 1943; 102 Mecca, Martin, Goldhaber (bib14) 1963; 113 Lowry, Roberts, Wu, Hixon, Crawford (bib10) 1944; 207 Gould (bib3) 1958; 232 |
| References_xml | – year: 1966 ident: bib8 publication-title: The influence of age on skeletal response to immobilization and ascorbic acid deficiency contributor: fullname: Omdahl – volume: 266 start-page: 289 year: 1957 ident: bib2 article-title: The influence of ascorbic acid on the proline, hydroxyproline, glycine, and collagen content of regenerating guinea pig skin publication-title: J. Biol. Chem contributor: fullname: Woessner – volume: 207 start-page: 19 year: 1944 ident: bib10 article-title: The quantitative histochemistry of brain. II. Enzyme measurements publication-title: J. Biol. Chem contributor: fullname: Crawford – volume: 53 start-page: 335 year: 1965 ident: bib4 article-title: Enzymatic hydroxylation of proline in microsomal polypeptide leading to formation of collagen publication-title: Proc. Nat. Acad. Sci contributor: fullname: Udenfriend – volume: 113 start-page: 538 year: 1963 ident: bib14 article-title: Alteration of bone metabolism in tissue culture in response to parathyroid extract publication-title: Proc. Soc. Exp. Biol. Med contributor: fullname: Goldhaber – volume: 31 start-page: 319 year: 1942 ident: bib6 article-title: The effect of ascorbic acid (vitamin C), calcium ascorbate and calcium gluconate on the regeneration of bone in rats publication-title: Quart. J. Exp. Physiol contributor: fullname: Bourne – volume: 122 start-page: 137 year: 1966 ident: bib16 article-title: Measurement of non-crystalline calcium phosphate in bone mineral publication-title: Proc. Soc. Exp. Biol. Med contributor: fullname: Posner – volume: 1113 start-page: 235 year: 1936 ident: bib9 article-title: A method to determine small amounts of citric acid in biological material publication-title: J. Biol. Chem contributor: fullname: Vickery – volume: 247 start-page: 2481 year: 1958 ident: bib11 article-title: Effet de la carence en vitamine C sur le metabolisme du calcium chez le cobaye publication-title: Compt. Rend contributor: fullname: Milhaud – start-page: 556 year: 1920 ident: bib15 article-title: Scurvy past present cited in Bourne, G. H publication-title: 1956 The Biochemistry and Physiology of Bone contributor: fullname: Hess – volume: 102 start-page: 319 year: 1943 ident: bib5 article-title: Some experiments on the possible relationship between vitamin C and calcification publication-title: J. Physiol contributor: fullname: Bourne – start-page: 174 year: 1956 ident: bib12 publication-title: Statistical Methods contributor: fullname: Snedecor – start-page: 551 year: 1956 ident: bib1 publication-title: The Biochemistry and Physiology of Bone contributor: fullname: Bourne – volume: 78 start-page: 3863 year: 1956 ident: bib13 article-title: On the mechanism of action of parathormone publication-title: J. Amer. Chem. Soc contributor: fullname: Distefano – volume: 1 start-page: 8 year: 1967 ident: bib17 article-title: Amorphous/crystalline interrelationships in bone mineral publication-title: Calcified Tissue Res contributor: fullname: Posner – volume: 232 start-page: 637 year: 1958 ident: bib3 article-title: Biosynthesis of collagen. III. The direct action of ascorbic acid on hydroxyproline and collagen formation in subcutaneous polyvinyl sponge implants in guinea pigs publication-title: J. Biol. Chem contributor: fullname: Gould – volume: 6 start-page: 527 year: 1954 ident: bib7 article-title: Uptake of radiosulphate and radiophosphate in various tissues of normal and scorbutic guinea pigs publication-title: Exp. Cell Res contributor: fullname: Ringertz |
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| Title | Effect of Ascorbic Acid Deprivation in Guinea Pigs on Skeletal Metabolism1 |
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