Sphingolipid Biosynthesis by Rat Liver Cells: Effects of Serine, Fatty Acids and Lipoproteins2

• Published in: The Journal of nutrition Vol. 119; no. 4; pp. 534 - 538
• Main Authors: Messmer, Trudy O., Wang, Elaine, Stevens, Victoria L., Merrill, Alfred H.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.04.1989
• Subjects: biosynthesis; cholesterol; lipoproteins; liver; palmitic acid; serine; sphingolipids; serine; sphingolipids; liver; biosynthesis; cholesterol; palmitic acid; lipoproteins

The effects of circulating factors that might influence de novo sphingolipid biosynthesis were examined with rat liver cells by following the incorporation of [14C]serine into sphingosine and sphinganine, the predominant long-chain base backbones of hepatic sphingolipids. The rate of long-chain base...