Mechanism of Prostaglandin E 2 Release and Increase in PGH 2 /PGE 2 Isomerase Activity by PDGF: Involvement of Nitric Oxide

• Published in: Archives of biochemistry and biophysics Vol. 312; no. 1; pp. 240 - 243
• Main Authors: Kelner, M.J., Uglik, S.F.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 1994

We examined the possibility that the platelet-derived growth factor-induced release of prostaglandin E 2 and increase in prostaglandin H 2 (PGH 2)/prostaglandin E 2 (PGE 2) isomerase activity (EC 5.3.99.3) in NIH3T3 cells was mediated by nitric oxide. Addition of L- N G-nitroarginine methyl ester or...